Publications

2021

Mechanosensitivity of nucleocytoplasmic transport; Ion AndreuIgnasi Granero-MoyaNimesh R. ChahareKessem CleinMarc Molina JordànAmy E. M. BeedleAlberto Elosegui-ArtolaXavier TrepatBarak Raveh, Pere Roca-Cusachs. bioRxiv, July 2021. DOI: https://doi.org/10.1101/2021.07.23.453478

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening; Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros & Pere Roca-Cusachs. Nature Communicacions, July 2021. DOI: https://doi.org/10.1038/s41467-021-24383-3

An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity; Jooske L. Monster, Lisa Donker, Marjolein J. Vliem, Zaw Win, Helen K. Matthews, Joleen S. Cheah, Soichiro Yamada, Johan de Rooij, Buzz Baum, Martijn Gloerich. Journal of Cell Biology, May 2021. DOI: https://doi.org/10.1083/jcb.202001042

Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations; Andrew Stannard, Marc Mora, Amy E. M. Beedle, Marta Castro-López, Stephanie Board and Sergi Garcia-Manyes. Nano Letters, March 2021. DOI: https://doi.org/10.1021/acs.nanolett.1c00051

The force loading rate drives cell mechanosensing through both reinforcement and fluidization; Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E.M. Beedle, Alberto Elósegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros, Pere Roca-Cusachs. bioRxiv, March 2021. DOI: https://doi.org/10.1101/2021.03.08.434428

A theory of ordering of elongated and curved proteins on membranes driven by density and curvature; Caterina Tozzi, Nikhil Walani, Anabel-Lise Le Roux, Pere Roca-Cusachs and Marino Arroyo. Soft Matter, March 2021. DOI: https://doi.org/10.1039/d0sm01733g

2020

Rethinking organoid technology through bioengineering; Elena Garreta, Roger D. Kamm, Susana M. Chuva de Sousa Lopes, Madeline A. Lancaster, Ron Weiss, Xavier Trepat, Insoo Hyun & Nuria Montserrat. Nature Materials, November 2020. DOI: https://doi.org/10.1038/s41563-020-00804-4

Protein nanomechanics: The power of stretching; Mora, M; Garcia-Manyes, S. Europhysics News (2020), 51/5, 24-27. DOI: https://doi.org/10.1051/epn/2020503

The nanomechanics of individual proteins; Marc Mora, Andrew Stannard, Sergi Garcia-Manyes. Chemical Society Reviews, October 2020. DOI: https://doi.org/10.1039/D0CS00426J

Dynamic Mechanochemical feedback between curved membranes and BAR protein self-organization; Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs. bioRxiv, September 2020. DOI: https://doi.org/10.1101/2020.09.23.310169

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion; M. Villiou, J.I. Paez, A. del Campo. ACS Appl. Mater. Interfaces 2020, July 2020 12(34), 37862. DOI: https://doi.org/10.1021/acsami.0c08568

Near-infrared-light regulated angiogenesis in a 4D hydrogel; Yijun Zheng, Zhijun Chen, Qiyang Jiang, Jun Feng, Si Wu, Aránzazu del Campo. Nanoscale, July 2020, 12(25), 13654-13661. DOI: https://doi.org/10.1039/d0nr02552f

Durotaxis; Raimon Sunyer; Xavier Trepat. Current Biol. May 2020, 30, R383-R387 DOI: https://doi.org/10.1016/j.cub.2020.03.051

The 2020 motile active matter roadmap; Gerhard Gompper et al. Journal of Physics: Condensed Matter. May 2020 DOI: https://doi.org/10.1088/1361-648x/ab6348

Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation; J.I. Paez, A. Farrukh, R. Valbuena Mendoza, M.K. Wlodarczyk-Biegun, A. del Campo. ACS Appl. Mater. Interfaces 2020, 12(7), 8062-8072. January 2020 DOI: https://doi.org/10.1021/acsami.0c00709

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues; Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li,  Jun Feng and Aránzazu del Campo. Material Horizons. January 2020 DOI: https://doi.org/10.1039/c9mh00665f

2019

Surface Tension Controls the Hydraulic Fracture of Adhesive Interfaces Bridged by Molecular Bonds; Dimitri Kaurin and Marino Arroyo. APS Physics, Physical Review Letters. November 2019 DOI: https://doi.org/10.1103/PhysRevLett.123.228102

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions; Danielle Park, Esther Wershof, Stefan Boeing, Anna Labernadie, Robert P. Jenkins, Samantha George, Xavier Trepat, Paul A. Bates & Erik Sahai. Nature Materials. October 2019 DOI: https://doi.org/10.1038/s41563-019-0504-3

Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro; Essak S Khan, Shrikrishnan Sankaran, Lorena LLontop, Aránzazu del Campo. bioRxiv. October 2019 DOI: https://doi.org/10.1101/803791

Embryonic self-fracking; Marino Arroyo, Xavier Trepat, Science. August 2019 DOI: 10.1126/science.aay2860

The plasma membrane as a mechanochemical transducer; Anabel-Lise Le Roux , Xarxa Quiroga , Nikhil Walani, Marino Arroyo and Pere Roca-Cusachs. The Royal Society, Biological Sciences, Philosofical transactions of the Royal Society B. July 2019 DOI: https://doi.org/10.1098/rstb.2018.0221

Possibilities and Limitations of Photoactivatable Cytochalasin D for the Spatiotemporal Regulation of Actin Dynamics; R.V. Nair, S. Zhao, E. Terriac, F. Lautenschläger, J.H.R. Hetmanski, P.T. Caswell, A. del Campo. ChemRxiv. July 2019. DOI: https://doi.org/10.26434/chemrxiv.12609545.v1

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues; Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li, Jun Feng and Aránzazu del Campo. Materials Horizons. July 2019 DOI: 10.1039/C9MH00665F

Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins; Caterina TozziNikhil Walani and Marino Arroyo. New Journal of Physics. July 2019 DOI: https://iopscience.iop.org/article/10.1088/1367-2630/ab3ad6

Force transduction by cadherin adhesions in morphogenesis; Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich. F1000Research Review.  July 2019 DOI: https://doi.org/10.12688/f1000research.18779.1

The mechanical stability of proteins regulates their translocation rate into the cell nucleus; Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs & Sergi Garcia-Manyes. Nature Physics. July 2019. DOI: https://doi.org/10.1038/s41567-019-0551-3

The mechanics of single cross-links which mediate cell attachment at a hydrogel surface; Arzu Çolak, Bin Li, Johanna Blass, Kaloian Koynov, Aranzazu del Campo and Roland Bennewitz. Nanoscale journal. June 2019 DOI: 10.1039/C9NR01784D

Integrins as biomechanical sensors of the microenvironment; Jenny Z. Kechagia, Johanna Ivaska & Pere Roca-Cusachs. Nature Reviews Molecular Cell Biology. June 2019; DOI: https://doi.org/10.1038/s41580-019-0134-2

Modelling fluid deformable surfaces with an emphasis on biological interfaces; Alejandro Torres-Sánchez, Daniel Millán and Marino Arroyo. Journal of Fluid Mechanics, Cambridge University Press. June 2019. DOI: https://doi.org/10.1017/jfm.2019.341 

Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium ; Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna Marín-Llauradó, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ángel Raya & Xavier Trepat, Nature Materials, June 2019; DOI: 10.1038/s41563-019-0381-9 (2019) 

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness; Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt. Elsevier, Acta Biomaterialia, March 2019; DOI: https://doi.org/10.1016/j.actbio.2019.01.063

Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly; Khan, Essak S et al., Advanced Science, February 2019; DOI: https://doi.org/10.1002/advs.201801982

Cadherin mechanotransduction in leader-follower cell specification during collective migration; Khalil, A.A., Experimental Cell Research, March 2019; DOI: https://doi.org/10.1016/j.yexcr.2019.01.006

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells; Garreta et al., Nature Materials, February 2019; DOI: https://doi.org/10.1038/s41563-019-0287-6 

2018

4D Biomaterials for Light‐Guided Angiogenesis; Farrukh, A., Paez, J. I. & Campo, A. D. Advanced Functional Materials, December 2018; DOI: https://doi.org/10.1002/adfm.201807734

In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV; Aleeza Farrukh, Shifang Zhao, Julieta I. Paez , Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalié, Aránzazu del Campo. ACS Applied Materials & Interfaces, November 2018; DOI: 10.1021/acsami.8b15517

Active superelasticity in three-dimensional epithelia of controlled shape; Latorre, E. et al. Nature, October 2018; DOI: https://doi.org/10.1038/s41586-018-0671-4

Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis; Shellard, A., Szabó, A., Trepat, X. & Mayor, R. Science, October 2018; DOI: https://doi.org/10.1126/science.aau3301

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells; Thottacherry, J. J. et al. Nature Communications, October2018; DOI: https://doi.org/10.1038/s41467-018-06738-5

Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces; Anna Labernadie, Xavier Trepat. Current Opinion in Cell Biology, October 2018; DOI: https://doi.org/10.1016/j.ceb.2018.04.008

Active wetting of epithelial tissues; Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt & Xavier Trepat, September 2018; DOI: https://doi.org/10.1038/s41567-018-0279-5

Forcing the reversibility of a mechanochemical reaction; Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann & Sergi Garcia-Manyes, Nature Communications, August 2018; DOI: https://doi.org/10.1038/s41467-018-05115-6

Re-inforcing the cell death army in the fight against breast cancer; Oudenaarden, C. R. L., Robert A. H. Van De Ven & Derksen, P. W. B. August 2018; DOI: https://doi.org/10.1242/jcs.212563

A hybrid computational model for collective cell durotaxis; Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel, García-Aznar. Biomechanics and Modeling in Mechanobiology, August 2018; doi: https://doi.org/10.1007/s10237-018-1010-2

Mesoscale physical principles of collective cell organization; Xavier Trepat & Erik Sahai. Nature Physics, July 2018; DOI: https://doi.org/10.1038/s41567-018-0194-9

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer; Bruner HC, Derksen PWB. Cold Spring Harb Perspect Biol, June 2018; DOI: 10.1101/cshperspect.a029330

DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43; Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann and Sergi Garcia-Manyes. J. Phys. Chem. Lett. , June 2018; DOI: 10.1021/acs.jpclett.8b01494

A photoactivatable α5β1-specific integrin ligand; Roshna V. Nair, Aleeza Farrukh, Aranzazu del Campo. ChemBioChem, June 2018. DOI: https://doi.org/10.

E-catenin is a candidate tumor suppressor for the developmentof E-cadherin-expressing lobular-type breast cancer; Jolien S de Groot, Max AK Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas,  Suet‐Feung Chin,  Carlos Caldas,  Paul J van Diest,  Jos Jonkers,  Johan de Rooij, Patrick WB Derksen.  The Journal of Pathology, May 2018; DOI: https://doi.org/10.1002/path.5099

Photoactivatable Adhesive Ligands for Light‐Guided Neuronal Growth; Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aránzazu del Campo. ChemBioChem, May 2018; DOI: 10.1002/cbic.201800118

Toward Light-Regulated Living Biomaterials; Shrikrishnan Sankaran, Shifang Zhao, Christina Muth, Julieta Paez and Aránzazu del Campo. Advanced Science News, May 2018; DOI: https://doi.org/10.1002/advs.201800383

Regulation of cell cycle progression by cell–cell and cell–matrix forces; Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà & Xavier Trepat. Nature Cell Biology, May 2018; DOI: https://doi.org/10.1038/s41556-018-0107-2

Control of Mechanotransduction by Molecular Clutch Dynamics; Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs. Trends in Cell Biology, May 2018; DOI: https://doi.org/10.1016/j.tcb.2018.01.008

TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4; Kuipers, A. J. et al. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, April 2018; https://doi.org/10.1016/j.bbadis.2018.04.017

The force-dependent mechanisms of DnaK-mediated mechanical folding; Perales-Calvo, J., Giganti, D., Stirnemann, G., Garcia-Manyes, S. Science Advances February 2018; DOI: 10.1126/sciadv.aaq0243

Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms; Nils C.Gauthier and Pere Roca-Cusachs. Current Opinion in Cell Biology, February 2018. DOI: https://doi.org/10.1016/j.ceb.2017.12.014

Molecular clutch drives cell response to surface viscosity; Bennett, M., Cantini, M., Reboud, J., Cooper, J. M., Roca-Cusachs, P. and Salmeron-Sanchez, M. Proceedings of the National Academy of Sciences, January 2018; DOI: https://doi.org/10.1073/pnas.1710653115

2017

Force loading explains spatial sensing of ligands by cells; Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam and Pere Roca-Cusachs. Nature, December 2017; DOI: 10.1038/nature24662

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores; Alberto Elosegui-Artola, Ion Andreu, Amy E. M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes and Pere Roca-Cusachs. Cell, Nov. 2017; DOI: https://doi.org/10.1016/j.cell.2017.10.008

Long-lived force patterns and deformation waves at repulsive epithelial boundaries; Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer and Xavier Trepat.  Nature Materials, Sept. 2017; DOI: 10.1038/NMAT4972

Membrane tension controls adhesion positioning at the leading edge of cells; Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, and Nils C. Gauthier. JCB: Article, July 2017; DOI: 10.1083/jcb.201611117

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links; Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González and Pere Roca-Cusachs. Mol Biol Cell. July 2017; DOI:  10.1091/mbc.E17-01-0006

Quantifying forces in cell biology; Roca-Cusachs, P., Conte, V. and Trepat, X. Nature Cell Biology, June 2017; DOI:10.1038/ncb3564

Amoebae as mechanosensitive tanks. Elosegui-Artola, A. and Roca-Cusachs, P. Biophysical Journal, June 2017; DOI: https://doi.org/10.1016/j.bpj.2017.05.020