Publications

2018

Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces; Anna Labernadie, Xavier Trepat. Current Opinion in Cell Biology, October 2018; DOI: https://doi.org/10.1016/j.ceb.2018.04.008

Active wetting of epithelial tissues; Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt & Xavier Trepat, September 2018; DOI: https://doi.org/10.1038/s41567-018-0279-5

A hybrid computational model for collective cell durotaxis; Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel, García-Aznar. Biomechanics and Modeling in Mechanobiology, August 2018; doi: https://doi.org/10.1007/s10237-018-1010-2

Mesoscale physical principles of collective cell organization; Xavier Trepat & Erik Sahai. Nature Physics, July 2018; DOI: https://doi.org/10.1038/s41567-018-0194-9

DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43; Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann and Sergi Garcia-Manyes. J. Phys. Chem. Lett. , June 2018; DOI: 10.1021/acs.jpclett.8b01494

A photoactivatable α5β1-specific integrin ligand; Roshna V. Nair, Aleeza Farrukh, Aranzazu del Campo. ChemBioChem, June 2018. DOI: https://doi.org/10.

E-catenin is a candidate tumor suppressor for the developmentof E-cadherin-expressing lobular-type breast cancer; Jolien S de Groot, Max AK Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas,  Suet‐Feung Chin,  Carlos Caldas,  Paul J van Diest,  Jos Jonkers,  Johan de Rooij, Patrick WB Derksen.  The Journal of Pathology, May 2018; DOI: https://doi.org/10.1002/path.5099

Toward Light-Regulated Living Biomaterials; Shrikrishnan Sankaran, Shifang Zhao, Christina Muth, Julieta Paez and Aránzazu del Campo. Advanced Science News, May 2018; DOI: https://doi.org/10.1002/advs.201800383

Regulation of cell cycle progression by cell–cell and cell–matrix forces; Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà & Xavier Trepat. Nature Cell Biology, May 2018; DOI: https://doi.org/10.1038/s41556-018-0107-2

Control of Mechanotransduction by Molecular Clutch Dynamics; Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs. Trends in Cell Biology, May 2018; DOI: https://doi.org/10.1016/j.tcb.2018.01.008

Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth; Aleeza Farrukh  Wenqiang Fan  Shifang Zhao  Marcelo Salierno  Julieta I. Paez Aránzazu del Campo. ChemBioChem, April 2018. DOI: https://doi.org/10.1002/cbic.201800118

The force-dependent mechanisms of DnaK-mediated mechanical folding; Perales-Calvo, J., Giganti, D., Stirnemann, G., Garcia-Manyes, S. Science Advances February 2018; DOI: 10.1126/sciadv.aaq0243

Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms; Nils C.Gauthier and Pere Roca-Cusachs. Current Opinion in Cell Biology, February 2018. DOI: https://doi.org/10.1016/j.ceb.2017.12.014

Molecular clutch drives cell response to surface viscosity; Bennett, M., Cantini, M., Reboud, J., Cooper, J. M., Roca-Cusachs, P. and Salmeron-Sanchez, M. Proceedings of the National Academy of Sciences, January 2018; DOI: https://doi.org/10.1073/pnas.1710653115

2017

Force loading explains spatial sensing of ligands by cells; Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam and Pere Roca-Cusachs. Nature, December 2017; DOI: 10.1038/nature24662

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores; Alberto Elosegui-Artola, Ion Andreu, Amy E. M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes and Pere Roca-Cusachs. Cell, Nov. 2017; DOI: https://doi.org/10.1016/j.cell.2017.10.008

Antoine A. Khalil, Olga Ilina, Pavlo G. Gritsenko, Peter Bult, Paul N. Span, Peter Friedl (2018). Collective invasion in ductal and lobular breast cancer associates with distant metastasis. Clinical & Experimental Metastasis, October 2017, Volume 34, Issue 6–7, pp 421–429

Long-lived force patterns and deformation waves at repulsive epithelial boundaries; Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer and Xavier Trepat.  Nature Materials, Sept. 2017; DOI: 10.1038/NMAT4972

Membrane tension controls adhesion positioning at the leading edge of cells; Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, and Nils C. Gauthier. JCB: Article, July 2017; DOI: 10.1083/jcb.201611117

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links; Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González and Pere Roca-Cusachs. Mol Biol Cell. July 2017; DOI:  10.1091/mbc.E17-01-0006

Quantifying forces in cell biology; Roca-Cusachs, P., Conte, V. and Trepat, X. Nature Cell Biology, June 2017; DOI:10.1038/ncb3564

NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma. Neri, L., Lasa, M., Elosegui-Artola, A., D’Avola, D., Carte, B., Gazquez, C., Alve, S., Roca-Cusachs, P., Iñarrairaegui, M., Herrero, J., Prieto, J., Sangro, B. and Aldabe, R. Oncotarget, June 2017; DOI: 10.18632/oncotarget.17332

Amoebae as mechanosensitive tanks. Elosegui-Artola, A. and Roca-Cusachs, P. Biophysical Journal, June 2017; DOI: https://doi.org/10.1016/j.bpj.2017.05.020

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Labernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., Alcaraz, J., Roca-Cusachs, P., Sahai, E. and Trepat, X. A Nature Cell Biology, February 2017; DOI:10.1038/ncb3478