The force loading rate drives cell mechanosensing through both reinforcement and fluidization;Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E.M. Beedle, Alberto Elósegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros, Pere Roca-Cusachs. bioRxiv, March 2021. DOI:

A theory of ordering of elongated and curved proteins on membranes driven by density and curvature; Caterina Tozzi, Nikhil Walani, Anabel-Lise Le Roux, Pere Roca-Cusachs and Marino Arroyo. Soft Matter, March 2021. DOI:


Rethinking organoid technology through bioengineering; Elena Garreta, Roger D. Kamm, Susana M. Chuva de Sousa Lopes, Madeline A. Lancaster, Ron Weiss, Xavier Trepat, Insoo Hyun & Nuria Montserrat. Nature Materials, November 2020. DOI:

Protein nanomechanics: The power of stretching; Mora, M; Garcia-Manyes, S. Europhysics News (2020), 51/5, 24-27. DOI:

The nanomechanics of individual proteins; Marc Mora, Andrew Stannard, Sergi Garcia-Manyes. Chemical Society Reviews, October 2020. DOI:

Dynamic Mechanochemical feedback between curved membranes and BAR protein self-organization; Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs. bioRxiv, September 2020. DOI:

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion; M. Villiou, J.I. Paez, A. del Campo. ACS Appl. Mater. Interfaces 2020, July 2020 12(34), 37862. DOI:

Near-infrared-light regulated angiogenesis in a 4D hydrogel; Yijun Zheng, Zhijun Chen, Qiyang Jiang, Jun Feng, Si Wu, Aránzazu del Campo. Nanoscale, July 2020, 12(25), 13654-13661. DOI:

Durotaxis; Raimon Sunyer; Xavier Trepat. Current Biol. May 2020, 30, R383-R387 DOI:

The 2020 motile active matter roadmap; Gerhard Gompper et al. Journal of Physics: Condensed Matter. May 2020 DOI:

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions; Danielle Park, Esther Wershof, Stefan Boeing, Anna Labernadie, Robert P. Jenkins, Samantha George, Xavier Trepat, Paul A. Bates & Erik Sahai. Nature Materials 19, pages 227–238. February 2020 DOI:

Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation; J.I. Paez, A. Farrukh, R. Valbuena Mendoza, M.K. Wlodarczyk-Biegun, A. del Campo. ACS Appl. Mater. Interfaces 2020, 12(7), 8062-8072. January 2020 DOI:

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues; Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li,  Jun Feng and Aránzazu del Campo. Material Horizons. January 2020 DOI:


Leader cell activity and collective invasion by an autocrine nucleotide loop through connexin-43 hemichannels and ADORA1; Antoine A. KhalilOlga Ilina, Angela VasaturoJan-Hendrik Venhuizen,Manon VullingsVictor VenhuizenAb Bilos Carl Figdor Paul N. Span, Peter Friedl. bioRxiv. December 2019 DOI:

Surface Tension Controls the Hydraulic Fracture of Adhesive Interfaces Bridged by Molecular Bonds; Dimitri Kaurin and Marino Arroyo. APS Physics, Physical Review Letters. November 2019 DOI:

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions; Danielle Park, Esther Wershof, Stefan Boeing, Anna Labernadie, Robert P. Jenkins, Samantha George, Xavier Trepat, Paul A. Bates & Erik Sahai. Nature Materials. October 2019 DOI:

Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro; Essak S Khan, Shrikrishnan Sankaran, Lorena LLontop, Aránzazu del Campo. bioRxiv. October 2019 DOI:

Embryonic self-fracking; Marino Arroyo, Xavier Trepat, Science. August 2019 DOI: 10.1126/science.aay2860

The plasma membrane as a mechanochemical transducer; Anabel-Lise Le Roux , Xarxa Quiroga , Nikhil Walani, Marino Arroyo and Pere Roca-Cusachs. The Royal Society, Biological Sciences, Philosofical transactions of the Royal Society B. July 2019 DOI:

Possibilities and Limitations of Photoactivatable Cytochalasin D for the Spatiotemporal Regulation of Actin Dynamics; R.V. Nair, S. Zhao, E. Terriac, F. Lautenschläger, J.H.R. Hetmanski, P.T. Caswell, A. del Campo. ChemRxiv. July 2019. DOI:

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues; Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li, Jun Feng and Aránzazu del Campo. Materials Horizons. July 2019 DOI: 10.1039/C9MH00665F

Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins; Caterina TozziNikhil Walani and Marino Arroyo. New Journal of Physics. July 2019 DOI:

Force transduction by cadherin adhesions in morphogenesis; Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich. F1000Research Review.  July 2019 DOI:

The mechanical stability of proteins regulates their translocation rate into the cell nucleus; Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs & Sergi Garcia-Manyes. Nature Physics. July 2019. DOI:

The mechanics of single cross-links which mediate cell attachment at a hydrogel surface; Arzu Çolak, Bin Li, Johanna Blass, Kaloian Koynov, Aranzazu del Campo and Roland Bennewitz. Nanoscale journal. June 2019 DOI: 10.1039/C9NR01784D

Integrins as biomechanical sensors of the microenvironment; Jenny Z. Kechagia, Johanna Ivaska & Pere Roca-Cusachs. Nature Reviews Molecular Cell Biology. June 2019; DOI:

Modelling fluid deformable surfaces with an emphasis on biological interfaces; Alejandro Torres-Sánchez, Daniel Millán and Marino Arroyo. Journal of Fluid Mechanics, Cambridge University Press. June 2019. DOI: 

Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium ; Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna Marín-Llauradó, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ángel Raya & Xavier Trepat, Nature Materials, June 2019; DOI: 10.1038/s41563-019-0381-9 (2019) 

Printability study of metal ion crosslinked PEG-catechol based inks; Małgorzata K. Włodarczyk-Biegun, Julieta I. Paez, Maria Villiou, Jun Feng, Aranzazu del Campo. Biofabrication; April 2019 (Pre-print) 

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness; Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt. Elsevier, Acta Biomaterialia, March 2019; DOI:

Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly; Khan, Essak S et al., Advanced Science, February 2019; DOI:

Cadherin mechanotransduction in leader-follower cell specification during collective migration; Khalil, A.A., Experimental Cell Research, March 2019; DOI:

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells; Garreta et al., Nature Materials, February 2019; DOI: 


4D Biomaterials for Light‐Guided Angiogenesis; Farrukh, A., Paez, J. I. & Campo, A. D. Advanced Functional Materials, December 2018; DOI:

In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV; Aleeza Farrukh, Shifang Zhao, Julieta I. Paez , Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalié, Aránzazu del Campo. ACS Applied Materials & Interfaces, November 2018; DOI: 10.1021/acsami.8b15517

Active superelasticity in three-dimensional epithelia of controlled shape; Latorre, E. et al. Nature, October 2018; DOI:

Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis; Shellard, A., Szabó, A., Trepat, X. & Mayor, R. Science, October 2018; DOI:

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells; Thottacherry, J. J. et al. Nature Communications, October2018; DOI:

Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces; Anna Labernadie, Xavier Trepat. Current Opinion in Cell Biology, October 2018; DOI:

Active wetting of epithelial tissues; Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt & Xavier Trepat, September 2018; DOI:

Forcing the reversibility of a mechanochemical reaction; Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann & Sergi Garcia-Manyes, Nature Communications, August 2018; DOI:

Re-inforcing the cell death army in the fight against breast cancer; Oudenaarden, C. R. L., Robert A. H. Van De Ven & Derksen, P. W. B. August 2018; DOI:

A hybrid computational model for collective cell durotaxis; Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel, García-Aznar. Biomechanics and Modeling in Mechanobiology, August 2018; doi:

Mesoscale physical principles of collective cell organization; Xavier Trepat & Erik Sahai. Nature Physics, July 2018; DOI:

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer; Bruner HC, Derksen PWB. Cold Spring Harb Perspect Biol, June 2018; DOI: 10.1101/cshperspect.a029330

DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43; Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann and Sergi Garcia-Manyes. J. Phys. Chem. Lett. , June 2018; DOI: 10.1021/acs.jpclett.8b01494

A photoactivatable α5β1-specific integrin ligand; Roshna V. Nair, Aleeza Farrukh, Aranzazu del Campo. ChemBioChem, June 2018. DOI:

E-catenin is a candidate tumor suppressor for the developmentof E-cadherin-expressing lobular-type breast cancer; Jolien S de Groot, Max AK Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas,  Suet‐Feung Chin,  Carlos Caldas,  Paul J van Diest,  Jos Jonkers,  Johan de Rooij, Patrick WB Derksen.  The Journal of Pathology, May 2018; DOI:

Photoactivatable Adhesive Ligands for Light‐Guided Neuronal Growth; Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aránzazu del Campo. ChemBioChem, May 2018; DOI: 10.1002/cbic.201800118

Toward Light-Regulated Living Biomaterials; Shrikrishnan Sankaran, Shifang Zhao, Christina Muth, Julieta Paez and Aránzazu del Campo. Advanced Science News, May 2018; DOI:

Regulation of cell cycle progression by cell–cell and cell–matrix forces; Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà & Xavier Trepat. Nature Cell Biology, May 2018; DOI:

Control of Mechanotransduction by Molecular Clutch Dynamics; Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs. Trends in Cell Biology, May 2018; DOI:

TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4; Kuipers, A. J. et al. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, April 2018;

The force-dependent mechanisms of DnaK-mediated mechanical folding; Perales-Calvo, J., Giganti, D., Stirnemann, G., Garcia-Manyes, S. Science Advances February 2018; DOI: 10.1126/sciadv.aaq0243

Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms; Nils C.Gauthier and Pere Roca-Cusachs. Current Opinion in Cell Biology, February 2018. DOI:

Molecular clutch drives cell response to surface viscosity; Bennett, M., Cantini, M., Reboud, J., Cooper, J. M., Roca-Cusachs, P. and Salmeron-Sanchez, M. Proceedings of the National Academy of Sciences, January 2018; DOI:


Force loading explains spatial sensing of ligands by cells; Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam and Pere Roca-Cusachs. Nature, December 2017; DOI: 10.1038/nature24662

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores; Alberto Elosegui-Artola, Ion Andreu, Amy E. M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes and Pere Roca-Cusachs. Cell, Nov. 2017; DOI:

Antoine A. Khalil, Olga Ilina, Pavlo G. Gritsenko, Peter Bult, Paul N. Span, Peter Friedl (2018). Collective invasion in ductal and lobular breast cancer associates with distant metastasis. Clinical & Experimental Metastasis, October 2017, Volume 34, Issue 6–7, pp 421–429

Long-lived force patterns and deformation waves at repulsive epithelial boundaries; Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer and Xavier Trepat.  Nature Materials, Sept. 2017; DOI: 10.1038/NMAT4972

Membrane tension controls adhesion positioning at the leading edge of cells; Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, and Nils C. Gauthier. JCB: Article, July 2017; DOI: 10.1083/jcb.201611117

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links; Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González and Pere Roca-Cusachs. Mol Biol Cell. July 2017; DOI:  10.1091/mbc.E17-01-0006

Quantifying forces in cell biology; Roca-Cusachs, P., Conte, V. and Trepat, X. Nature Cell Biology, June 2017; DOI:10.1038/ncb3564

NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma. Neri, L., Lasa, M., Elosegui-Artola, A., D’Avola, D., Carte, B., Gazquez, C., Alve, S., Roca-Cusachs, P., Iñarrairaegui, M., Herrero, J., Prieto, J., Sangro, B. and Aldabe, R. Oncotarget, June 2017; DOI: 10.18632/oncotarget.17332

Amoebae as mechanosensitive tanks. Elosegui-Artola, A. and Roca-Cusachs, P. Biophysical Journal, June 2017; DOI:

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Labernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., Alcaraz, J., Roca-Cusachs, P., Sahai, E. and Trepat, X. A Nature Cell Biology, February 2017; DOI:10.1038/ncb3478