2023
TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity. Gallego-Paez, L. M., Edwards, W. J. S., Chanduri, M., Guo, Y., Koorman, T., Lee, C. Y., Grexa, N., Derksen, P., Yan, J., Schwartz, M. A., Mauer, J., & Goult, B. T. Journal of Cell Biology. March 2023. DOI: https://doi.org/10.1083/jcb.202209010
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells. Sluimer, L. M., Bullock, E., Rätze, M. A. K., Enserink, L., Overbeeke, C., Hornsveld, M., Brunton, V. G., Derksen, P. W. B., & Tavares, S. Journal of cell science. January 2023. DOI: https://doi.org/10.1242/jcs.260243
Multimodal Techniques to Study Tumor Growth, Basement Membrane Breaching, and Invasion in 3D Matrices. Daan Smits, Antoine A. Khalil. Cell Migration in Three Dimensions. Part of the Methods in Molecular Biology book series. January 2023. DOI: https://doi.org/10.1007/978-1-0716-2887-4_17
2022
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system. Lolo FN, Walani N, Seemann E, Zalvidea D, Pavón DM, Cojoc G, Zamai M, Viaris de Lesegno C, Martínez de Benito F, Sánchez-Álvarez M, Uriarte JJ, Echarri A, Jiménez-Carretero D, Escolano JC, Sánchez SA, Caiolfa VR, Navajas D, Trepat X, Guck J, Lamaze C, Roca-Cusachs P, Kessels MM, Qualmann B, Arroyo M, Del Pozo MA. Nature Cell Biology. December 2022. DOI: http://doi.org/10.1038/s41556-022-01034-3
Gelation Kinetics and Mechanical Properties of Thiol‐Tetrazole MethylsulfoneHydrogels Designed for Cell Encapsulation. Adrián de Miguel-Jiménez,Bastian Ebeling,Julieta I. Paez,Claudia Fink-Straube,Samuel Pearson,Aránzazu del Campo. Macromolecular Bioscience. December 2022. DOI: https://doi.org/10.1002/mabi.202200419
Stiffness-dependent active wetting enables optimal collective cell durotaxis. Macià Esteve Pallarès, Irina Pi-Jaumà, Isabela Corina Fortunato, Valeria Grazu, Manuel Gómez-González, Pere Roca-Cusachs, Jesus M. de la Fuente, Ricard Alert, Raimon Sunyer, Jaume Casademunt & Xavier Trepat. Nature Physics. December 2022. DOI: https://doi.org/10.1038/s41567-022-01835-1
Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape. Tapia-Rojo, R*; Mora, M*; Board, S.J.; Walker, J; Boujemaa-Paterski, R.; Medalia, O; Garcia-Manyes, S. Nature Physics. November 2022. DOI: https://doi.org/10.1038/s41567-022-01808-4
Cardiac fibroblasts and mechanosensation in heart development, health and disease. Maurizio Pesce, Georg N. Duda, Giancarlo Forte, Henrique Girao, Angel Raya, Pere Roca-Cusachs, Joost P. G. Sluijter, Carsten Tschöpe & Sophie Van Linthout. Nature Review Cardiology. November 2022. DOI: https://doi.org/10.1038/s41569-022-00799-2
Cell response to extracellular matrix energy dissipation outweighs rigidity sensing. Carla Huerta-López, Alejandro Clemente-Manteca, Diana Velázquez-Carreras, Francisco M. Espinosa, Juan G. Sanchez, Pablo Sáez, Álvaro Martínez-del-Pozo, María García-García, Sara Martín-Colomo, Andrea Rodríguez-Blanco, Ricardo Esteban-González, View ORCID ProfileFrancisco M. Martín-Zamora, Luis I. Gutierrez-Rus, Ricardo García, Pere Roca-Cusachs, Alberto Elosegui-Artola, Miguel A. del Pozo, Elías Herrero-Galán, Gustavo R. Plaza, Jorge Alegre-Cebollada. bioRxiv. November 2022. DOI: https://doi.org/10.1101/2022.11.16.516826
LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice. Eline J. ter Steege; Thijmen Sijnesael; Lotte Enserink; Sjoerd Klarenbeek; Wisse E. Haakma; Elvira R.M. Bakker; Patrick W.B. Derksen. Neoplasia Volume 35. November 2022. DOI: https://doi.org/10.1016/j.neo.2022.100844
A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1. Donker L, Houtekamer R, Vliem M, Sipieter F, Canever H, Gómez-González M, Bosch-Padrós M, Pannekoek WJ, Trepat X, Borghi N, Gloerich M. Cell reports. October 2022. DOI: http://doi.org/10.1016/j.celrep.2022.111475
The role of single-protein elasticity in mechanobiology. Amy E. M. Beedle, Sergi Garcia-Manyes. Nature Reviews Materials volume 8, pages10–24. October 2022. DOI: https://doi.org/10.1038/s41578-022-00488-z
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina. Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gomez-Gonzalez, Laura M. Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarne, David Barata, Isabela C. Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, and Claudio A. Franco. Developmental Cell Volume 57, Issue 19, P2321-2333.E9. September 2022. DOI: https://doi.org/10.1016/j.devcel.2022.09.002
Positive, negative and engineered durotaxis. P. Sáez and C. Venturini. BioRxiv. September 2022. DOI: https://doi.org/10.1101/2022.09.26.508682
Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility. Chiara Zambarda, Carlos Perez Gonzalez, Andreas Schoenit, Nisha Veits, Clara Schimmer, Raimund Jung, Dirk Ollech, Joel Christian, Pere Roca-Cusachs, Xavier Trepat , Elisabetta Ada Cavalcanti-Adam. European Journal of Cell Biology, Volume 101, Issue 4. September 2022. DOI: https://doi.org/10.1016/j.ejcb.2022.151274
A novel cancer-associated cassette exon in TLN1 alters Talin 1 mechanosensitivity. Lina M. Gallego-Paez1, William J.S. Edwards, Yanyu Guo, Manasa Chanduri, Thijs Koorman, Chieh-Yu Lee, Nina Grexa, Patrick W. B. Derksen, Jie Yan, Martin A. Schwartz, Jan Mauer and Benjamin T. Goult. bioRxiv. September 2022. DOI: https://doi.org/10.1101/2022.09.06.506802
Mechanical strain stimulates COPII‐dependent secretory trafficking via Rac1. Santosh Phuyal, Elena Djaerff, Anabel-Lise Le Roux, Martin J Baker, Daniela Fankhauser, Sayyed Jalil Mahdizadeh, Veronika Reiterer, Amirabbas Parizadeh, Edward Felder,Jennifer C Kahlhofer, David Teis, Marcelo G Kazanietz, Stephan Geley, Leif Eriksson, Pere Roca-Cusachs & Hesso Farhan. The EMBO Journal 41:e110596. August 2022. DOI: https://doi.org/10.15252/embj.2022110596
How talin allosterically activates vinculin. Florian Franz, Rafael Tapia-Rojo, Sabina Katz, Rajaa Boujemaa-Paterski, Wenhong Li, Tamar Unger, Shira Albeck, Camilo Aponte-Santamaría, Sergi Garcia-Manyes, Ohad Medalia, Benjamin Geiger, Frauke Gräter. Research Square. August 2022. DOI: https://doi.org/10.21203/rs.3.rs-1906540/v1
Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway. Martina Lerche, Mathilde Mathieu, Lene Malerød, Nina Marie Pedersen, Hellyeh Hamidi, Megan Chastney, Bart Marlon Herwig Bruininks, Shreyas Kaptan, Guillaume Jacquemet, Ilpo Vattulainen, Pere Roca-Cusachs, Andreas Brech, Franck Perez, Gaelle Boncompain, Stéphanie Miserey and Johanna Ivaska. bioRxiv. July 2022. DOI: https://doi.org/10.1101/2022.07.12.498931
Geometry-driven migration efficiency of minimal cell clusters. Eléonore Vercurysse, David B. Brückner, Manuel Gómez-González, Marine Luciano, Yohalie Kalukula, Leone Rossetti, Xavier Trepat, Edouard Hannezo and Sylvain Gabriele. July 2022. bioRvix DOI: https://doi.org/10.1101/2022.07.17.500364
Understanding the role of mechanics in nucleocytoplasmic transport. Ion Andreu, Ignasi Granero-Moya, Sergi Garcia-Manyes and Pere Roca-Cusachs. APL Bioengineering 6, 020901. June 2022. DOI: https://doi.org/10.1063/5.0076034
Mechanical force application to the nucleus regulates nucleocytoplasmic transport. Ion Andreu, Ignasi Granero-Moya, Nimesh R. Chahare, Kessem Clein, Marc Molina-Jordán, Amy E. M. Beedle, Alberto Elosegui-Artola, Juan F. Abenza, Leone Rossetti, Xavier Trepat, Barak Raveh, Pere Roca-Cusachs. Nature Cell Biology volume 24, pages896–905. June 2022. DOI: https://doi.org/10.1038/s41556-022-00927-7
Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking. Dimitri Kaurin, Pradeep K. Bal, Marino Arroyo. J. R. Soc. Interface 19: 20220183. June 01, 2022. DOI: https://doi.org/10.1098/rsif.2022.0183
Mapping mechanical stress in curved epithelia of designed size and shape. Ariadna Marín-Llauradó, Sohan Kale, Adam Ouzeri, Raimon Sunyer, Alejandro Torres Sánchez, Ernest Latorre, Manuel Gómez-González, Pere Roca-Cusachs, Marino Arroyo, Xavier Trepat. bioRxiv. May 2022. DOI: https://doi.org/10.1101/2022.05.03.490382
A Single-Molecule Strategy to Capture Non-native Intramolecular and Intermolecular Protein Disulfide Bridges. Marc Mora, Stephanie Board, Olivier Languin-Cattoën, Laura Masino, Guillaume Stirnemann, Sergi Garcia-Manyes. Nano Lett. 22, 10, 3922–3930. May 2022. DOI: https://doi.org/10.1021/acs.nanolett.2c00043
Self-generated gradients steer collective migration on viscoelastic collagen networks. Andrew G. Clark, Ananyo Maitra, Cécile Jacques , Martin Bergert , Carlos Pérez-González, Anthony Simon, Luc Lederer , Alba Diz-Muñoz, Xavier Trepat, Raphaël Voituriez, Danijela Matic Vignjevic. Nature Materials volume 21, pages1200–1210. DOI: https://doi.org/10.1038/s41563-022-01259-5
Binding of anisotropic curvature-inducing proteins onto membrane tubes. Hiroshi Noguchi, Caterina Tozzi and Marino Arroyo. Soft Matter 18, 3384-3394. May 2022. DOI: https://doi.org/10.1039/d2sm00274d
Elastomeric Optical Waveguides by Extrusion Printing. Jun Feng, Yijun Zheng, Qiyang Jiang, Małgorzata K. Włodarczyk-Biegun, Samuel Pearson, and Aránzazu del Campo. Advanced Materials Technologies Volumen 7, Issue 10. April 2022. DOI: https://doi.org/10.1002/admt.202101539
Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer. Max A. K. Rätze, Thijs Koorman, Thijmen Sijnesael, Blessing Bassey-Archibong, Robert van de Ven, Lotte Enserink, Daan Visser, Sridevi Jaksani, Ignacio Viciano, Elvira R. M. Bakker, François Richard, Andrew Tutt, Lynda O’Leary, Amanda Fitzpatrick, Pere Roca-Cusachs, Paul J. van Diest, Christine Desmedt, Juliet M. Daniel, Clare M. Isacke and Patrick W. B. Derksen. Oncogene 41, 2932-2944. April 2022. DOI: https://doi.org/10.1038/s41388-022-02314-w
FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer. Sandra Tavares, Nalan Liv, Milena Pasolli, Mark Opdam, Max A.K. Rätze, Manuel Saornil, Lilian M. Sluimer, Rutger C.C. Hengeveld, Robert van Es, Erik van Werkhoven, Harmjan Vos, Holger Rehmann,
Boudewijn M.T. Burgering, Hendrika M. Oosterkamp, Susanne M.A. Lens, Judith Klumperman, Sabine C. Linn, Patrick W.B. Derksen. Cell reports, VOLUME 39, ISSUE 1, 110584, April 05, 2022. DOI: https://doi.org/10.1016/j.celrep.2022.110584
Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment. Thijs Koorman, Karin A. Jansen, Antoine Khalil, Peter D. Haughton, Daan Visser, Max A. K. Rätze, Wisse E. Haakma, Gabrielè Sakalauskaitè, Paul J. van Diest, Johan de Rooij and Patrick W. B. Derksen. Oncogene 41, 2458-2469, March 2022. DOI: https://doi.org/10.1038/s41388-022-02258-1
The laminin-keratin link shields the nucleus from mechanical deformation and signalling. , , , , , , , , , ,
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells. , , , , , , , ,
Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD. J, , , , , , , , ,
Mechanical strain stimulates COPII-dependent trafficking via Rac1. , , , , , , , , , , , , ,
2021
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair. Wallis SS, Ventimiglia, LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M. Developmental Cell. December 2021. DOI: https://doi.org/10.1016/j.devcel.2021.10.022
Digesting the mechanobiology of the intestinal epithelium. Carlos Pérez-González, Gerardo Ceada, Marija Matejčić, Xavier Trepat. Current Opinion in Genetics & Development, 72, 82-90. December 2021. DOI: https://doi.org/10.1016/j.gde.2021.10.005
Competition for endothelial cell polarity drives vascular morphogenesis. Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gómez-González, Laura M. Faure, Georgia Zarkada, Andreia A. Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarné, David Barata, Isabela Fortunato, Lenka H. Misiková, Ian Mauldin,Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, Cláudio A. Franco. bioRxiv, November 2021. DOI: https://doi.org/10.1101/2021.11.23.469704
Dynamic Mechanochemical feedback between curved membranes and BAR protein self-organization; Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani , Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs. Nat Commun 12, 6550 (2021). DOI: https://doi.org/10.1038/s41467-021-26591-3
Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions. George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V. Lee, Jos Jonkers, Valerie G. Brunton, Matthias Christgen, Clare Isacke, Patrick W. B. Derksen, and Cathrin Brisken. MDPI, Cancers 2021, 13(21), 5396; October 2021. DOI: https://doi.org/10.3390/cancers13215396
Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo. Samuel Pearson, Jun Feng, Aránzazu del Campo. Advanced Functional MaterialsVolume 31, Issue 50. September 2021. DOI: https://doi.org/10.1002/adfm.202105989
A mechanosensing mechanism mediated by IRSp53 controls plasma membrane shape homeostasis at the nanoscale; Xarxa Quiroga, Nikhil Walani, Albert Chavero, Alexandra Mittens, Andrea Disanza, Francesc Tebar, Xavier Trepat, Robert G. Parton,Giorgio Scita, Maria Isabel Geli, Marino Arroyo, Anabel-Lise Le Roux, Pere Roca-Cusachs. bioRxiv, August 2021. DOI: https://doi.org/10.1101/2021.08.01.454667
Mechanosensitivity of nucleocytoplasmic transport; , , , , , , , , ,
The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening; Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros & Pere Roca-Cusachs. Nature Communicacions, July 2021. DOI: https://doi.org/10.1038/s41467-021-24383-3
Thiol-Methylsulfone-Based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-Methylsulfone Substrate for Fine-Tunable Gelation Rate and Improved Stability. Julieta I. Paez, Adrián de Miguel-Jiménez, Rocío Valbuena-Mendoza, Aditi Rathore, Minye Jin, Alisa Gläser, Samuel Pearson, and Aránzazu del Campo. American Chemical Society, Biomacromolecules, 22(7), 2874-2886. June 2021. DOI: https://doi.org/10.1021/acs.biomac.1c00256
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration. Carlos Pérez-González, Gerardo Ceada, Francesco Greco, Marija Matejčić, Manuel Gómez-González, Natalia Castro, Anghara Menendez, Sohan Kale, Denis Krndija, Andrew G. Clark, Venkata Ram Gannavarapu, Adrián Álvarez-Varela, Pere Roca-Cusachs, Eduard Batlle, Danijela Matic Vignjevic, Marino Arroyo & Xavier Trepat. Nature Cell Biology volume 23, pages745–757. June 2021. DOI: https://doi.org/10.1038/s41556-021-00699-6
An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity; Jooske L. Monster, Lisa Donker, Marjolein J. Vliem, Zaw Win, Helen K. Matthews, Joleen S. Cheah, Soichiro Yamada, Johan de Rooij, Buzz Baum, Martijn Gloerich. Journal of Cell Biology, May 2021. DOI: https://doi.org/10.1083/jcb.202001042
Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations; Andrew Stannard, Marc Mora, Amy E. M. Beedle, Marta Castro-López, Stephanie Board and Sergi Garcia-Manyes. Nano Letters, March 2021. DOI: https://doi.org/10.1021/acs.nanolett.1c00051
The force loading rate drives cell mechanosensing through both reinforcement and fluidization; Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E.M. Beedle, Alberto Elósegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros, Pere Roca-Cusachs. bioRxiv, March 2021. DOI: https://doi.org/10.1101/2021.03.08.434428
A theory of ordering of elongated and curved proteins on membranes driven by density and curvature; Caterina Tozzi, Nikhil Walani, Anabel-Lise Le Roux, Pere Roca-Cusachs and Marino Arroyo. Soft Matter, March 2021. DOI: https://doi.org/10.1039/d0sm01733g
2020
Rethinking organoid technology through bioengineering; Elena Garreta, Roger D. Kamm, Susana M. Chuva de Sousa Lopes, Madeline A. Lancaster, Ron Weiss, Xavier Trepat, Insoo Hyun & Nuria Montserrat. Nature Materials, November 2020. DOI: https://doi.org/10.1038/s41563-020-00804-4
Protein nanomechanics: The power of stretching; Mora, M; Garcia-Manyes, S. Europhysics News (2020), 51/5, 24-27. DOI: https://doi.org/10.1051/epn/2020503
The nanomechanics of individual proteins; Marc Mora, Andrew Stannard, Sergi Garcia-Manyes. Chemical Society Reviews, October 2020. DOI: https://doi.org/10.1039/D0CS00426J
Dynamic Mechanochemical feedback between curved membranes and BAR protein self-organization; Anabel-Lise Le Roux, Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo, Pere Roca-Cusachs. bioRxiv, September 2020. DOI: https://doi.org/10.1101/2020.09.23.310169
Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion; M. Villiou, J.I. Paez, A. del Campo. ACS Appl. Mater. Interfaces 2020, July 2020 12(34), 37862. DOI: https://doi.org/10.1021/acsami.0c08568
Near-infrared-light regulated angiogenesis in a 4D hydrogel; Yijun Zheng, Zhijun Chen, Qiyang Jiang, Jun Feng, Si Wu, Aránzazu del Campo. Nanoscale, July 2020, 12(25), 13654-13661. DOI: https://doi.org/10.1039/d0nr02552f
Durotaxis; Raimon Sunyer; Xavier Trepat. Current Biol. May 2020, 30, R383-R387 DOI: https://doi.org/10.1016/j.cub.2020.03.051
The 2020 motile active matter roadmap; Gerhard Gompper et al. Journal of Physics: Condensed Matter
Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation; J.I. Paez, A. Farrukh, R. Valbuena Mendoza, M.K. Wlodarczyk-Biegun, A. del Campo. ACS Appl. Mater. Interfaces 2020, 12(7), 8062-8072. January 2020 DOI: https://doi.org/10.1021/acsami.0c00709
4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues; Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li, Jun Feng and Aránzazu del Campo.
2019
Surface Tension Controls the Hydraulic Fracture of Adhesive Interfaces Bridged by Molecular Bonds; Dimitri Kaurin and Marino Arroyo. APS Physics, Physical Review Letters. November 2019 DOI: https://doi.org/10.1103/PhysRevLett.123.228102
Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions; Danielle Park, Esther Wershof, Stefan Boeing, Anna Labernadie, Robert P. Jenkins, Samantha George, Xavier Trepat, Paul A. Bates & Erik Sahai. Nature Materials. October 2019 DOI: https://doi.org/10.1038/s41563-019-0504-3
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro; Essak S Khan, Shrikrishnan Sankaran, Lorena LLontop, Aránzazu del Campo. bioRxiv. October 2019 DOI: https://doi.org/10.1101/803791
Embryonic self-fracking; Marino Arroyo, Xavier Trepat, Science. August 2019 DOI: 10.1126/science.aay2860
The plasma membrane as a mechanochemical transducer; Anabel-Lise Le Roux , Xarxa Quiroga , Nikhil Walani, Marino Arroyo and Pere Roca-Cusachs. The Royal Society, Biological Sciences, Philosofical transactions of the Royal Society B. July 2019 DOI: https://doi.org/10.1098/rstb.2018.0221
Possibilities and Limitations of Photoactivatable Cytochalasin D for the Spatiotemporal Regulation of Actin Dynamics; R.V. Nair, S. Zhao, E. Terriac, F. Lautenschläger, J.H.R. Hetmanski, P.T. Caswell, A. del Campo. ChemRxiv. July 2019. DOI: https://doi.org/10.26434/chemrxiv.12609545.v1
4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues; Yijun Zheng, Mitchell Kim Liong Han, Qiyang Jiang, Bin Li, Jun Feng and Aránzazu del Campo. Materials Horizons. July 2019 DOI: 10.1039/C9MH00665F
Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins; Caterina Tozzi, Nikhil Walani and Marino Arroyo. New Journal of Physics. July 2019 DOI: https://iopscience.iop.org/article/10.1088/1367-2630/ab3ad6
Force transduction by cadherin adhesions in morphogenesis; Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich. F1000Research Review. July 2019 DOI: https://doi.org/10.12688/f1000research.18779.1
The mechanical stability of proteins regulates their translocation rate into the cell nucleus; Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs & Sergi Garcia-Manyes. Nature Physics. July 2019. DOI: https://doi.org/10.1038/s41567-019-0551-3
The mechanics of single cross-links which mediate cell attachment at a hydrogel surface; Arzu Çolak, Bin Li, Johanna Blass, Kaloian Koynov, Aranzazu del Campo and Roland Bennewitz. Nanoscale journal. June 2019 DOI: 10.1039/C9NR01784D
Integrins as biomechanical sensors of the microenvironment; Jenny Z. Kechagia, Johanna Ivaska & Pere Roca-Cusachs. Nature Reviews Molecular Cell Biology. June 2019; DOI: https://doi.org/10.1038/s41580-019-0134-2
Modelling fluid deformable surfaces with an emphasis on biological interfaces; Alejandro Torres-Sánchez, Daniel Millán and Marino Arroyo. Journal of Fluid Mechanics, Cambridge University Press. June 2019. DOI: https://doi.org/10.1017/jfm.2019.341
Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium ; Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna Marín-Llauradó, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ángel Raya & Xavier Trepat, Nature Materials, June 2019; DOI: 10.1038/s41563-019-0381-9 (2019)
Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness; Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt. Elsevier, Acta Biomaterialia, March 2019; DOI: https://doi.org/10.1016/j.actbio.2019.01.063
Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly; Khan, Essak S et al., Advanced Science, February 2019; DOI: https://doi.org/10.1002/advs.201801982
Cadherin mechanotransduction in leader-follower cell specification during collective migration; Khalil, A.A., Experimental Cell Research, March 2019; DOI: https://doi.org/10.1016/j.yexcr.2019.01.006
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells; Garreta et al., Nature Materials, February 2019; DOI: https://doi.org/10.1038/s41563-019-0287-6
2018
4D Biomaterials for Light‐Guided Angiogenesis; Farrukh, A., Paez, J. I. & Campo, A. D. Advanced Functional Materials, December 2018; DOI: https://doi.org/10.1002/adfm.201807734
In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV; Aleeza Farrukh, Shifang Zhao, Julieta I. Paez , Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalié, Aránzazu del Campo. ACS Applied Materials & Interfaces, November 2018; DOI: 10.1021/acsami.8b15517
Active superelasticity in three-dimensional epithelia of controlled shape; Latorre, E. et al. Nature, October 2018; DOI: https://doi.org/10.1038/s41586-018-0671-4
Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis; Shellard, A., Szabó, A., Trepat, X. & Mayor, R. Science, October 2018; DOI: https://doi.org/10.1126/science.aau3301
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells; Thottacherry, J. J. et al. Nature Communications, October2018; DOI: https://doi.org/10.1038/s41467-018-06738-5
Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces; Anna Labernadie, Xavier Trepat. Current Opinion in Cell Biology, October 2018; DOI: https://doi.org/10.1016/j.ceb.2018.04.008
Active wetting of epithelial tissues; Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader, Manuel Gómez-González, Tomasz Kolodziej, Elsa Bazellieres, Jaume Casademunt & Xavier Trepat, September 2018; DOI: https://doi.org/10.1038/s41567-018-0279-5
Forcing the reversibility of a mechanochemical reaction; Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann & Sergi Garcia-Manyes, Nature Communications, August 2018; DOI: https://doi.org/10.1038/s41467-018-05115-6
Re-inforcing the cell death army in the fight against breast cancer; Oudenaarden, C. R. L., Robert A. H. Van De Ven & Derksen, P. W. B. August 2018; DOI: https://doi.org/10.1242/jcs.212563
A hybrid computational model for collective cell durotaxis; Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel, García-Aznar. Biomechanics and Modeling in Mechanobiology, August 2018; doi: https://doi.org/10.1007/s10237-018-1010-2
Mesoscale physical principles of collective cell organization; Xavier Trepat & Erik Sahai. Nature Physics, July 2018; DOI: https://doi.org/10.1038/s41567-018-0194-9
Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer; Bruner HC, Derksen PWB. Cold Spring Harb Perspect Biol, June 2018; DOI: 10.1101/cshperspect.a029330
DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43; Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann and Sergi Garcia-Manyes. J. Phys. Chem. Lett. , June 2018; DOI: 10.1021/acs.jpclett.8b01494
A photoactivatable α5β1-specific integrin ligand; Roshna V. Nair, Aleeza Farrukh, Aranzazu del Campo. ChemBioChem, June 2018. DOI: https://doi.org/10.
E-catenin is a candidate tumor suppressor for the developmentof E-cadherin-expressing lobular-type breast cancer; Jolien S de Groot, Max AK Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet‐Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick WB Derksen. The Journal of Pathology, May 2018; DOI: https://doi.org/10.1002/path.5099
Photoactivatable Adhesive Ligands for Light‐Guided Neuronal Growth; Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aránzazu del Campo. ChemBioChem, May 2018; DOI: 10.1002/cbic.201800118
Toward Light-Regulated Living Biomaterials; Shrikrishnan Sankaran, Shifang Zhao, Christina Muth, Julieta Paez and Aránzazu del Campo. Advanced Science News, May 2018; DOI: https://doi.org/10.1002/advs.201800383
Regulation of cell cycle progression by cell–cell and cell–matrix forces; Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà & Xavier Trepat. Nature Cell Biology, May 2018; DOI: https://doi.org/10.1038/s41556-018-0107-2
Control of Mechanotransduction by Molecular Clutch Dynamics; Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs. Trends in Cell Biology, May 2018; DOI: https://doi.org/10.1016/j.tcb.2018.01.008
TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4; Kuipers, A. J. et al. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, April 2018; https://doi.org/10.1016/j.bbadis.2018.04.017
The force-dependent mechanisms of DnaK-mediated mechanical folding; Perales-Calvo, J., Giganti, D., Stirnemann, G., Garcia-Manyes, S. Science Advances February 2018; DOI: 10.1126/sciadv.aaq0243
Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms; Nils C.Gauthier and Pere Roca-Cusachs. Current Opinion in Cell Biology, February 2018. DOI: https://doi.org/10.1016/j.ceb.2017.12.014
Molecular clutch drives cell response to surface viscosity; Bennett, M., Cantini, M., Reboud, J., Cooper, J. M., Roca-Cusachs, P. and Salmeron-Sanchez, M. Proceedings of the National Academy of Sciences, January 2018; DOI: https://doi.org/10.1073/pnas.1710653115
2017
Force loading explains spatial sensing of ligands by cells; Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam and Pere Roca-Cusachs. Nature, December 2017; DOI: 10.1038/nature24662
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores; Alberto Elosegui-Artola, Ion Andreu, Amy E. M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes and Pere Roca-Cusachs. Cell, Nov. 2017; DOI: https://doi.org/10.1016/j.cell.2017.10.008
Long-lived force patterns and deformation waves at repulsive epithelial boundaries; Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer and Xavier Trepat. Nature Materials, Sept. 2017; DOI: 10.1038/NMAT4972
Membrane tension controls adhesion positioning at the leading edge of cells; Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, and Nils C. Gauthier. JCB: Article, July 2017; DOI: 10.1083/jcb.201611117
Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links; Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González and Pere Roca-Cusachs. Mol Biol Cell. July 2017; DOI: 10.1091/mbc.E17-01-0006
Quantifying forces in cell biology; Roca-Cusachs, P., Conte, V. and Trepat, X. Nature Cell Biology, June 2017; DOI:10.1038/ncb3564
Amoebae as mechanosensitive tanks. Elosegui-Artola, A. and Roca-Cusachs, P. Biophysical Journal, June 2017; DOI: https://doi.org/10.1016/j.bpj.2017.05.020