This past 2019 has been a great success concerning the outreach activities carried out within the Mechano·Control project. More than 320 people attended talks, workshops, discussions… related to mechanobiology.
Each year IBEC organises several workshops on mechanobiology where students explore how cells exert forces and they measure them and also create a cell membrane model. This year three schools with 25 students each have participated in this programme. Also, once a year 24 students that participate in a larger programme called “Crazy about bioengineering” come to Pere Roca-Cusachs and Trepat’s lab to do hands-on sessions on how cells perceive the surrounding environment, mechanobiology and biochemical responses.
London participated at the 2019 Pint of Science with a talk on how forces are
key to unveiling how life functions with an audience of more than 50 people
from different ages and backgrounds.
three presentations throughout the year addressed to patients and general
public about their research line on breast cancer, where more than 130 attended
Last but not least, INM also organised two experimental activities at their laboratories reaching 40 students and also mentoring lab practice to 5 secondary school students.
Pere Roca-Cusachs, coordinator of the Mechano·Control project and PI at the Institute for Bioengineering of Catalonia has been interviewed for the European Comission Digital Single Market news section.
Through the interview by Giordano Zambelli, Pere unfolds the aim of the project and it’s impact to society and also explains his experience working with FET.
Finding effective solutions to fight cancer is undoubtedly one of the main scientific challenges worldwide, whose success needs necessarily to build on innovative pathways of research. Mechano-Control aims to understand the physical forces that determine the spread of a wide range of diseases, with potentially vast impact on the development of new therapies.
The Mechano·Control project has launched a series of videos describing the aim of the project. In order to reach a broad audience and bring the reaserch closer to society and making it understandable, the first video explains through cartoons, the aim of the project and the research that is being carried out by the consortium members. The second video, shows the researchers behind the project. Mechano·Control is focused on the mechanical control of the biological function with the aim abrogate breast tumour progression.
More than 60 people attended the “Mechanobiology of Cancer Summer School 2019” organised by the Mechano·Control consortium. The summer school was held in Prullans, a tiny village located at the Catalan Pyrenees between 17 and 21 of September. The event was a great success both in participation and scientific level. The aim of the summer school was to provide training on mechanobiology, and specifically its application to breast cancer, and promote interactions between professionals of the field. The school included lectures as well as practical workshops in different techniques and disciplines, ranging from modelling to biomechanics to cancer biology.
The morning sessions where dedicated to the keynote sessions from leading researchers in the mechanobiology field. The sessions left room to exchange opinions and doubts between the participants and the speakers. On the first day, Guillaume Salbreux (Francis Crick Institute) gave a lecture on “Physics of epithelial deformations” and Buzz Baum (Francis Crick Institute) on “Cancer cell division”. The second day started with Marija Plodinec’s (University Hospital Basel) keynote on “Nanomechanical profiling of living epithelial tissues in health and disease and potential applications in routine clinical setting” followed by Peter Friedl’s (St. Radboud University Nijmegen Medical Centre) intervention on Plasticity of adhesion and matrix guidance in cancer invasion and metastasis”. The last day started with Andrew Ewald (Johns Hopkins University School of Medicine for Cell Dynamics) and his talk on “Novel roles of cell adhesion in breast cancer metastasis” and to finish with the scientific sessions, Christina Scheel (St. Josef Hospital, Ruhr-University Bochum) with her lecture “Dynamic collagen deformation drives branching morphogenesis in mammary organoids derived from human breast tissue“.
The keynote sessions were followed by short talks from the attendees of the summer school, which created a space for sharing knowledge and exchanging the different research that is being carried out in different institutions around the world.
The afternoon sessions where more interactive and hands-on sessions with six different workshops organised by the Mechano·Control members. Marino Arroyo (Universitat Politècnica de Catalunya) gave an interactive workshop on “Vertex modelling in biomechanics” using the Matlab programme, Sergi Garcia-Manyes (King’s College London) on “Single molecule mechanics”, Manuel Gómez from Xavi Trepat’s lab (Institute for Bioengineering of Catalonia) on “Traction force microscopy”, Menno de Jong and Onno van den Boomen (Noviocell) on “Gel mechanics”, Patrick Derksen (University Medical Center Utrecht) on “Fundamentals of breast cancer biology” and Julieta Páez and Gulistan Kocer (Leibniz Institute for New Materials) on the “Chemistry of tuneable gels”.
Finally, the last day there was a poster session, where amongst the 30 posters, the keynote speakers had to give an award to the best poster. Adam Ouzeri, PhD at LaCaN – Cell and tissue mechanobiology, from Universitat Politècnica de Catalunya (UPC) won the prize for his poster “Upscaling active gel models of the actin cortex to epithelial mechanics”.
Not everything would be training, there was also time for leisure and social activities to promote networking between the participants, PI’s and keynote speakers. There was a hiking trip and a visit to the green house located near the hotel.
The ability to control key forces that drive biological functioning would be a boon for a number of medical fields. With a focus on breast cancer, an EU-funded project is bringing together different research communities to work towards understanding and controlling cellular mechanics.
Mechanical forces are created inside the body through the action of specific molecular bonds. Being able to control these would enable a giant leap forward in fields such as oncology, regenerative medicine and biomaterial design.
Tapping the potential of cellular mechanics requires the development and integration of a number of disparate technologies. The EU-funded MECHANO-CONTROL project is addressing this challenge, assembling an interdisciplinary team to design and carry out pertinent research. The scientists involved are specifically targeting new ways to impair or abrogate breast tumour progression.
The project’s ultimate aim is to understand and learn to control the full range of cellular mechanics. To do so, scientists need to find new ways to measure and manipulate complex cellular processes – from the nanometre to the metre scale.
At all stages, the MECHANO-CONTROL team is integrating experimental data with multi-scale computational modelling. With this approach, the aim is to develop specific therapeutic approaches beyond the current paradigm in breast cancer treatment.
Going further, the general principles delineated by MECHANO-CONTROL could also have high applicability in other areas of oncology, as well as regenerative medicine and biomaterials. This has the potential to bring new treatments and relief from suffering for many.
Taking it scale by scale
Working at the nanometric, molecular level, MECHANO-CONTROL researchers are developing cellular microenvironments, enabled by substances that mimic naturally occurring cell components.
On the cell-to-organ scale, the team is combining controlled microenvironments and interfering strategies with the development of techniques to measure and control mechanical forces and adhesion in cells and tissues, and to evaluate their biological response.
At the organism scale, researchers are establishing how cellular mechanics can be controlled.
Last 5th-10th May was held the 2019 Gordon Research Conference on “Fibronectin, Integrins and Related Molecules” where Pere Roca-Cusachs from IBEC and Antoine Khalil from UMCU presented talks discussing Mechanocontrol results on how mechanical signals and the extracellular matrix regulate cell responses and tumour invasion. During the keynote session titled “Mechanisms and Mechanics of Integrin ECM Connections” Pere Roca-Cusachs gave a talk on “Exploring the Substrate Dependence of Integrin-Mediated Mechanotransduction”. Antoine gave an oral presentation where he described how cell-ECM adhesion regulates the positioning of basal cells and their specification into invasive leader cells during collective invasion of breast cancer organoids.
The Gordon Research Conference was held in Lucca, Italy and is the premier international conference for academic, government and industry scientists interested in understanding how integrins and the extracellular matrix regulate virtually every aspect of cell and tissue function. The program of the conference reflected the interdisciplinary nature of the integrin and extracellular matrix field, spanning different areas of biology from inflammation to mechanobiology, cell migration, stem cells, development, and cancer. During the meeting unpublished data was highlighted and stimulated active discussion among all participants.
The application period opens today until the 8th May 2019, where you can submint an abstract if you are interested in giving a short talk during the summer school.
The application does not guarantee acceptance to the Summer School due to the limited number of participants, an email with the resolution of the applicaton process will be sent on June 15th 2019.
The summer school will be held in La Cerdanya at the Eco-Resort located in Prullans in the Catalan Pyrenees.
The participation fee is 300€ (taxes not included) and includes accomodation in shared double room (from 17th-20th September 2019), full-board, workshops and conferences, leisure activities and shuttle bus from Barcelona to the venue.
hosting two members from the Mechano·Control network. On the one hand, Dimitri
Kaurin, PhD student from Marino Arroyo group at Universitat Politècnica de
Catalunya (UPC) that will be staying at IBEC for at least one year and on the
other hand, Amy Beedle, postdoc from Sergi Garcia-Manyes at Kings College
Dimitri Kaurin started his stay at Pere Roca-Cusachs’ laboratory in December 2018 and it is planned to be for at least a year. One of the objectives of Dimitri’s stay is to work on a protocol to study cell-cell adhesion using a controlled system based on lipid bilayers of controlled viscosity. “Using AFM technique, we expect to access some information about cell-cell adhesion under force” says Dimitri. In the context of this research he will also visit Manuel Salmeron laboratory in Glasgow University this march to learn some techniques about functionalizing lipid bilayers with cadherins.
On the other hand, Amy Beedle arrived this past January to Pere Roca-Cusachs’ laboratory. In the Garcia-Manyes lab Amy was looking at how mechanical forces can trigger conformational changes in individual proteins. Here at IBEC, she wants to incorporate the results at the single molecule level with the cellular level, to try to understand how individual bonds and proteins can contribute to cellular mechanosensing. “My aim is to expand my expertise in single molecule force spectroscopy to a larger cellular context” adds Amy.
This is the first time that both UPC and KCL teams meet with IBEC to share skills and ideas within the project’s framework.
EBSA association grants this prize every two years. The last winner of the prize was Philipp Kukura from the University of Oxford in the UK in 2017. The prize recognises an investigator across Europe who has defended his thesis 12 years ago or less and awards him with 2000€ and a medal as well as be expected to contribute an article to the European Biophysics Journal. The decision of the winning researcher is made by the Executive Committee based on scientific excellence, leadership and creativity.
The European Biophysical Societies Association was formed in 1984 as a non-profit making organisation, with the objectives “to advance and disseminate knowledge of the principles, recent developments and applications of biophysics, and to foster the exchange of scientific information among European biophysicists and biophysicists in general”. It is composed of the Biophysical Societies in the European area and is managed by an Executive Committee. EBSA is associated with the international organizations International Union for Pure and Applied Biophysics (IUPAB) and Initiative for Science in Europe (ISE) and owns the European Biophysics Journal.
consortium, led by several research institutions across Europe, is launching a
Summer School that will be taking place between 17-20 of September 2019 at the
Eco Resort in La Cerdanya. The aim of the summer school is to provide training
on mechanobiology, and specifically its application to breast cancer.
This school will include lectures as well as practical workshops in different
techniques and disciplines, ranging from modelling to biomechanics to cancer
There will be scientific sessions in the morning, mixing 6
keynote speakers with 18 short talks selected from abstract submissions by
junior scientists attending the school. In the afternoon, there will be 2-3-hour
practical workshops, given by scientists from the MECHANO·CONTROL consortium.
The course will also include leisure activities.
to the Summer School is open to all students, post-docs, and professionals
interested, although priority will be given to junior scientists (up to
will be launching the Mechanobiology of Cancer Summer School 2019 website,
where you will find more information about the activities that will be held
during the summer school, information on how to register, and the deadlines
both for the registration and abstract submission.
confirmed speakers who will attend the summer school are:
Marija Plodinec (University Hospital Basel)
Andrew Ewald (Johns Hopkins University School of
Peter Friedl (Radboud University Nijmegen)
Guillaume Salbreux (Francis Crick Institute)
Christina Scheel (Institute of Stem Cell Research,
Helmholtz Center Munich)
Buzz Baum (Medical Research Council
Laboratory for Molecular Cell Biology at UCL)
Also, all MECHANO·CONTROL consortium members will be attending the summer school and will be giving some of the workshops: Aránzazu del Campo (Leibniz-Institut für Neue Materialien, INM), Sergi Garcia-Manyes (King’s College London, KCL), Pere Roca-Cusachs and Xavier Trepat (Institute for Bioengineering of Catalonia, IBEC), Patrick Derksen and Johan de Rooij (University Medical Center Utrecht, UMCU), Marino Arroyo (Universitat Politècnica de Catalunya, UPC) and the companies NovioCell and Mind the Byte.
list of workshop topics:
of tuneable gels
TheMECHANO·CONTROL project is focused on the mechanical control of biological function.Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control holds an uncharted potential in oncology, regenerative medicine and biomaterial design.
MECHANO·CONTROL proposes to address
this challenge by building an interdisciplinary research community with the aim
of understanding and controlling cellular mechanics from the molecular to the
organism scale. At all stages and scales of the project, it will integrate
experimental data with multi-scale computational modelling to establish the
rules driving biological response to mechanics and adhesion. With this
approach, it aims to explore novel therapeutic approaches beyond the current
paradigm in breast cancer treatment. If the partners can understand cancer
biomechanics from the single molecule to the whole organ scale, they’ll be able
to control mechanical forces to restore healthy cell behaviour and inhibit
Beyond breast cancer, the general principles targeted with this technology will have high applicability in oncology, regenerative medicine, biomaterials and many other biological processes and diseases.
MECHANO·CONTROL is a project funded
by the European Commission, within the Future and Emerging Technologies (FET)